Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery.
نویسندگان
چکیده
A novel bone-targeted delivery systems based on nanocapsules was developed utilizing a Zeolitic Imidazolate Framework (ZIF-8) as a template and catechol-modified gelatin as wall material. A targeting ligand was facilely conjugated on the surface of nanocapsules. Simvastatin was encapsulated within the nanocapsules with a loading of 37.9%. Hydroxyapatite binding and in vivo biodistribution of the drug-loaded nanocapsules were investigated.
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ورودعنوان ژورنال:
- Biomaterials science
دوره 5 4 شماره
صفحات -
تاریخ انتشار 2017