Nanocapsules engineered from polyhedral ZIF-8 templates for bone-targeted hydrophobic drug delivery.

نویسندگان

  • Xiaoli Wang
  • Dandan Miao
  • Xiaoyu Liang
  • Jiayi Liang
  • Chao Zhang
  • Jing Yang
  • Deling Kong
  • Chun Wang
  • Hongfan Sun
چکیده

A novel bone-targeted delivery systems based on nanocapsules was developed utilizing a Zeolitic Imidazolate Framework (ZIF-8) as a template and catechol-modified gelatin as wall material. A targeting ligand was facilely conjugated on the surface of nanocapsules. Simvastatin was encapsulated within the nanocapsules with a loading of 37.9%. Hydroxyapatite binding and in vivo biodistribution of the drug-loaded nanocapsules were investigated.

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عنوان ژورنال:
  • Biomaterials science

دوره 5 4  شماره 

صفحات  -

تاریخ انتشار 2017